V komediji bomo priča zabavnim dogodivščinam nenavadnega policijskega para. Po sili razmer proti krutemu mamilarskemu botru združita moči dekleti, ki si ne bi mogli biti bolj različni. Sarah je zadrta agentka FBI in pikolovska preiskovalka, medtem ko je Shannon jezikava bostonska policistka, ki je odrasla na ulici in se pri reševanju zločinov največkrat zanaša na svoj šesti čut. Na začetku nobena izmed njiju ni navdušena nad novim partnerstvom, vendar se kmalu zgodi nepričakovano, saj postaneta pravi prijateljici.
Sarah Ashburn, an FBI agent, is extremely ambitious and has her eye on a promotion, but she doesn't get along with her co-workers. She is sent to Boston to uncover the identity of an elusive drug lord, Mr. Larkin, by tracking down his proxy, Rojas, and is told that she'll have a good shot at the promotion if she finds Larkin. When she arrives in Boston, she learns that Larkin has been eliminating his competition and taking over their operations. She learns that Rojas is in Boston PD custody and goes to see him to ask him what he knows about Larkin, but is warned that the cop who arrested Rojas, Shannon Mullins, is very territorial, and she is not exactly sociable. When the two meet they don't get along. When Mullins learns why Ashburn is in Boston, she decides to find Larkin herself. Ashburn is told by her boss to work with Mullins, but it won't be easy because Ashburn does things by the book while Mullins does things her way.