Temačna komedija režiserja Tima Burtona o življenju vampirja Barnabasa Collinsa in njegovih srečanjih z različnimi pošastmi, čarovnicami, volkodlaki in duhovi. Premožnega mladeniča Barnabasa ljubosumna čarovnica v 18. stoletju oropa ljubezni, spremeni v vampirja in zakoplje v temačni grob. Leta 1972 Barnabas znova vstane od mrtvih in priskoči na pomoč obubožanim in necenjenim potomcem svoje družine. Toda težko privajanje na tehnološki napredek in divji časi brezmejne ljubezni, drog in rock'n'rolla ga privedejo v številne zabavne težave. Poleg tega pa se mora soočiti tudi s smrtno sovražnico.
In the year 1752, Joshua and Naomi Collins, with young son Barnabas, set sail from Liverpool, England to start a new life in America. But even an ocean was not enough to escape the mysterious curse that has plagued their family. Two decades pass and Barnabas (Johnny Depp) has the world at his feet-or at least the town of Collinsport, Maine. The master of Collinwood Manor, Barnabas is rich, powerful and an inveterate playboy...until he makes the grave mistake of breaking the heart of Angelique Bouchard (Eva Green). A witch, in every sense of the word, Angelique dooms him to a fate worse than death: turning him into a vampire, and then burying him alive. Two centuries later, Barnabas is inadvertently freed from his tomb and emerges into the very changed world of 1972. He returns to Collinwood Manor to find that his once-grand estate has fallen into ruin. The dysfunctional remnants of the Collins family have fared little better, each harboring their own dark secrets. Matriarch Elizabeth Collins Stoddard (Michelle Pfeiffer) has called upon live-in psychiatrist, Dr. Julia Hoffman (Helena Bonham Carter), to help with her family troubles.